Insane adjective – Having or showing a very abnormal or sick state of mind. Abnormal and insane are semantically related. Sometimes you can use "Abnormal" instead an adjective "Insane". Nearby Words: insanity, insanely
This ended up having loads of Unfortunate Implications as it both made being female "abnormal" and the fact that Arcee went insane (rather understandably, considering the experiment amounted to a forced sex-change operation) had plenty of potential sexist/transphobic implications.