Crackers and Loco

Crackers

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Crackers adjective – Having or showing a very abnormal or sick state of mind.
Usage example: prisoners in that hellhole either died of disease or went crackers

Loco is a synonym for crackers in sane topic. In some cases you can use "Loco" instead an adjective "Crackers", when it comes to topics like insane. slang substitute
Synonyms for Crackers

Loco

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Loco adjective – Having or showing a very abnormal or sick state of mind.
Usage example: that dog's plumb loco, just running around in circles all day long

Crackers is a synonym for loco in sane topic. You can use "Crackers" instead an adjective "Loco". popular alternative
Synonyms for Loco
Cite this Source
Loco and Crackers. (2016). Retrieved 2019, October 16, from https://thesaurus.plus/related/crackers/loco
Crackers & Loco. N.p., 2016. Web. 16 Oct. 2019. <https://thesaurus.plus/related/crackers/loco>.
Loco or Crackers. 2016. Accessed October 16, 2019. https://thesaurus.plus/related/crackers/loco.

Synonyms for crackers
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Synonyms for loco
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Google Ngram Viewer shows how "crackers" and "loco" have occurred on timeline: