Demented and Loco

Demented

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Demented adjective – Having or showing a very abnormal or sick state of mind.
Usage example: a poor, demented animal that had obviously suffered years of abuse

Loco is a synonym for demented in sane topic. In some cases you can use "Loco" instead an adjective "Demented", when it comes to topics like crazy. slang substitute
Nearby Word: dementing
Synonyms for Demented

Loco

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Loco adjective – Having or showing a very abnormal or sick state of mind.
Usage example: that dog's plumb loco, just running around in circles all day long

Demented is a synonym for loco in sane topic. You can use "Demented" instead an adjective "Loco", if it concerns topics such as insane.
Synonyms for Loco
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Loco and Demented. (2016). Retrieved 2019, December 12, from https://thesaurus.plus/related/demented/loco
Demented & Loco. N.p., 2016. Web. 12 Dec. 2019. <https://thesaurus.plus/related/demented/loco>.
Loco or Demented. 2016. Accessed December 12, 2019. https://thesaurus.plus/related/demented/loco.

Synonyms for demented
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Synonyms for loco
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Google Ngram Viewer shows how "demented" and "loco" have occurred on timeline: