Most and Supreme

Most

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Most adjective – Of the greatest or highest degree or quantity.
Usage example: the player with the most ability on the tennis team

Supreme is a synonym for most in best topic. In some cases you can use "Supreme" instead the word "Most" as an adjective or a noun, when it comes to topics like ultimate, chief.
Nearby Word: mostly
Synonyms for Most

Supreme

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Supreme adjective – Of the greatest or highest degree or quantity.
Usage example: considers a letter of gratitude from a former student the supreme reward for his years of teaching

Most is a synonym for supreme. You can use "Most" instead the word "Supreme" as an adjective or a noun.
Nearby Word: supremely
Synonyms for Supreme
Cite this Source
Supreme and Most. (2016). Retrieved 2021, January 18, from https://thesaurus.plus/related/most/supreme
Most & Supreme. N.p., 2016. Web. 18 Jan. 2021. <https://thesaurus.plus/related/most/supreme>.
Supreme or Most. 2016. Accessed January 18, 2021. https://thesaurus.plus/related/most/supreme.

Synonyms for most
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Synonyms for supreme
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Google Ngram Viewer shows how "most" and "supreme" have occurred on timeline: