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Opposite words of insignificant
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stickies, post-it, list
blowing, bubbles
board, insignificance
depression, depressed, forlorn
board, insignificance
nothing, board, blackboard

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Antonyms for Insignificant. (2016). Retrieved 2021, December 03, from https://thesaurus.plus/antonyms/insignificant
Antonyms for Insignificant. N.p., 2016. Web. 03 Dec. 2021. <https://thesaurus.plus/antonyms/insignificant>.
Antonyms for Insignificant. 2016. Accessed December 03, 2021. https://thesaurus.plus/antonyms/insignificant.