Against
Against preposition - In or into contact with.
Despite is a synonym for against in regardless of topic. In some cases you can use "Despite" instead the word "Against" as an adverb or a preposition. popular alternative
Despite
Despite noun - Open dislike for someone or something considered unworthy of one's concern or respect.
Against is a synonym for despite in regardless of topic. You can use "Against" instead the word "Despite" as an adverb or a preposition, if it concerns topics such as in spite of. popular alternative
Mutual synonyms
Both words in one sentence
- To be human is to be flawed, limited, and finite; but to be a good human is to nonetheless struggle through and work against or despite these limitations.
Source: Humans Are Flawed -
Despite an armament of 52 missiles + 36 homing missiles, instead of using them against multiple targets, he invariably launches all of them in a single barrage against a few targets.
Source: Macross Missile Massacre - Despite declaring herself a villain, she has yet to perform an actual villainous act against Shore City, instead helping to capture or fight against several others.
Source: Roleplay / SupeRPowered
Cite this Source
Despite and Against. (2016). Retrieved 2026, August 15, from https://thesaurus.plus/related/against/despite
Against & Despite. N.p., 2016. Web. 15 Aug. 2026. <https://thesaurus.plus/related/against/despite>.
Despite or Against. 2016. Accessed August 15, 2026. https://thesaurus.plus/related/against/despite.
Google Ngram Viewer shows how "against" and "despite" have occurred on timeline