Agony and Despair

Agony

Agony noun - A situation or state that causes great suffering and unhappiness.

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Despair and agony are semantically related. In some cases you can use "Despair" instead a noun "Agony".

Despair noun - Utter loss of hope.

Usage example: the endless drought drove the farmers to despair

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Agony and despair are semantically related. Sometimes you can use "Agony" instead a noun "Despair".

emotional	emotional agony	emotional despair
human	human agony	human despair
pure	pure agony	pure despair
equal	equal agony	equal despair
Other adjectives: complete, utter, total, sheer, real, constant, severe, crushing, massive, extreme, great, intense, abject, absolute, personal, incredible, psychological, further, maximum, crippling, existential, suicidal.

She revels in causing humans pain and suffering, and compliments Mustang's determination while he's killing her, stating that one day soon, his eyes will widen with agony and despair.

Source: Card Carrying Villain / Anime and Manga
The narrator, with his psychic sensitivity, said that the agony, despair and sorrow those ensnared were feeling was so deep it quite literally was too much for his brain to even remotely fathom and sent him into a panic attack.

Source: Literature / The Night Land
Gloom, despair, and agony on me deep, dark depression, excessive misery if it weren't for bad luck, I'd have no luck at all gloom, despair, and agony on me.

Source: Series / Hee Haw

Cite this Source

Despair and Agony. (2016). Retrieved 2026, July 30, from https://thesaurus.plus/related/agony/despair

Agony & Despair. N.p., 2016. Web. 30 Jul. 2026. <https://thesaurus.plus/related/agony/despair>.

Despair or Agony. 2016. Accessed July 30, 2026. https://thesaurus.plus/related/agony/despair.

Google Ngram Viewer shows how "agony" and "despair" have occurred on timeline