As a whole and At large

At large and as a whole are semantically related in on the whole topic. In some cases you can use "At large" instead the phrase "As a whole" as an adjective or an adverb.

At large adverb - In a general fashion.

As a whole and at large are semantically related in in general topic. You can use "As a whole" instead the phrase "At large" as an adjective or an adverb, if it concerns topics such as on the whole.