Best
Best adjective - (superlative of `good') having the most positive qualities.
Significant and best are semantically related. In some cases you can use "Significant" instead an adjective "Best".
Significant
Significant adjective - Clearly conveying a special meaning (as one's mood).
Best and significant are semantically related. Sometimes you can use "Best" instead an adjective "Significant".
Mutual synonyms
Both words in one sentence
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Dawkins considers this his most significant and best scientific work.
Source: Useful Notes / Richard Dawkins -
Master of None: Hachiken is rather upset to find out that although he has the best grades overall (apparently by a pretty significant margin) he's not the best in any single subject.
Source: Manga / Silver Spoon - It seems that Hyakuji is full of characters who devoted a significant chunk of their lifetimes training to develop their powers and subsequently gaining a reputation as being among the best of the best at what they do.
Cite this Source
Significant and Best. (2016). Retrieved 2026, July 22, from https://thesaurus.plus/related/best/significant
Best & Significant. N.p., 2016. Web. 22 Jul. 2026. <https://thesaurus.plus/related/best/significant>.
Significant or Best. 2016. Accessed July 22, 2026. https://thesaurus.plus/related/best/significant.
Google Ngram Viewer shows how "best" and "significant" have occurred on timeline