Difficulty and Setback

Difficulty noun - Something that is a cause for suffering or special effort especially in the attainment of a goal.

Setback is a synonym for difficulty in impediment topic. In some cases you can use "Setback" instead a noun "Difficulty", when it comes to topics like mental burden.

Nearby Word: difficult

Setback noun - A change in status for the worse usually temporarily.

Difficulty is a synonym for setback in problem topic. You can use "Difficulty" instead a noun "Setback", if it concerns topics such as impediment, disappointment.