Down
Down verb - To strike (someone) so forcefully as to cause a fall.
Take effect and down are semantically related In some cases you can use "Take effect" instead a verb "Down".
Nearby Word: downed
Take effect
Take effect verb - Go into effect or become effective or operative.
Down and take effect are semantically related in occur topic. Sometimes you can use "Down" instead a verb phrase "Take effect".
Mutual synonyms
Both terms in one sentence
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Injected drugs in Psionics: The Next Stage in Human Evolution start to take effect immediately, so powerful sedatives can put a character down instantly.
Source: Instant Sedation -
The episode "The Broca Divide" has both sides of this: early in the episode, they have to tie a thrashing character down and wait for the sedative to take effect; later, they go into another thrasher's isolation room, hold him steady, and inject him, making him stagger within 10 seconds.
Source: Instant Sedation - Awesome, yet Impractical: The Hara Hara attacks are incredibly powerful (Politank-Z's can even take down a character at full health) but they're telegraphed by loud sirens and a warning screen, and take a few seconds to actually take effect.
Source: Video Game / Waku Waku 7
Cite this Source
Take effect and Down. (2016). Retrieved 2026, July 22, from https://thesaurus.plus/related/down/take_effect
Down & Take effect. N.p., 2016. Web. 22 Jul. 2026. <https://thesaurus.plus/related/down/take_effect>.
Take effect or Down. 2016. Accessed July 22, 2026. https://thesaurus.plus/related/down/take_effect.
Google Ngram Viewer shows how "down" and "take effect" have occurred on timeline