Extinction and Loss

Extinction

Extinction noun - The state or fact of being rendered nonexistent, physically unsound, or useless.

Usage example: the state's population of moose has been replenished, having once been hunted almost to extinction

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Loss and extinction are semantically related. In some cases you can use "Loss" instead a noun "Extinction".

Nearby Word: extinct

Loss noun - The state or fact of being rendered nonexistent, physically unsound, or useless.

Usage example: the loss of the oil tanker was more significant than the loss of its cargo

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Extinction and loss are semantically related. Sometimes you can use "Extinction" instead a noun "Loss".

Nearby Word: losing

human	human extinction	human loss
similar	similar extinction	similar loss
complete	complete extinction	complete loss
certain	certain extinction	certain loss
Other adjectives: utter, actual, massive, great, bad, potential, gradual, early, major, near, possible, final, apparent, outright, inevitable, subsequent, impending, eventual, greatest, recent, sudden, devastating.

It featured a sanity loss score for "knowingly and willingly causing the extinction of the human race." That was the second highest possible sanity loss.

Source: Video Game Cruelty Punishment
Star Trek IV: The Voyage Home (The One with... The Whales) has, as you may guess, a pretty strong message against hunting and exploiting species to extinction when the loss of humpback whales in the 21st century almost wrecks humanity in the 23rd.

Source: Green Aesop
For the guardians of the Last City on Earth, fighting killer robots who turned the planet into a bombed-out wasteland, with most loved ones dead and a single loss meaning total extinction, the characters are disturbingly peppy.

Source: Mood Dissonance