He and Male human

He noun - A very light colorless element that is one of the six inert gasses; the most difficult gas to liquefy; occurs in economically extractable amounts in certain natural gases (as those found in Texas and Kansas).

Male human and he are semantically related. In some cases you can use "Male human" instead a noun "He".

He and male human are semantically related. You can use "He" instead a noun phrase "Male human".