Heartache and Tribulation

Heartache noun - Deep sadness especially for the loss of someone or something loved.

Tribulation is a synonym for heartache in sorrow topic. In some cases you can use "Tribulation" instead a noun "Heartache", when it comes to topics like misery, agony.

Tribulation noun - A state of great suffering of body or mind.

Heartache is a synonym for tribulation in suffering topic. You can use "Heartache" instead a noun "Tribulation", if it concerns topics such as sorrow, misery, pain, agony.