In all seriousness and Out of whack

Out of whack and in all seriousness are semantically related. In some cases you can use "Out of whack" instead an adverb phrase "In all seriousness".

Out of whack adjective - Out of balance or out of adjustment.

In all seriousness and out of whack are semantically related. Sometimes you can use "In all seriousness" instead an adverb phrase "Out of whack".