In despair
Vain and in despair are semantically related. in hopeless topic. In some cases you can use "Vain" instead an adjective phrase "In despair", when it comes to topics like futile.
Vain
Vain adjective - Having too high an opinion of oneself.
In despair and vain are semantically related. Sometimes you can use "In despair" instead an adjective "Vain".
Cite this Source
Vain and In despair. (2016). Retrieved 2026, August 14, from https://thesaurus.plus/related/in_despair/vain
In despair & Vain. N.p., 2016. Web. 14 Aug. 2026. <https://thesaurus.plus/related/in_despair/vain>.
Vain or In despair. 2016. Accessed August 14, 2026. https://thesaurus.plus/related/in_despair/vain.
Google Ngram Viewer shows how "in despair" and "vain" have occurred on timeline