In point of fact and Of course

In point of fact adverb - In reality or actuality.

Of course and in point of fact are semantically related. in really topic. In some cases you can use "Of course" instead an adverb phrase "In point of fact", when it comes to topics like actually, without a doubt.

Of course adverb - As might be expected.

In point of fact and of course are semantically related. Sometimes you can use "In point of fact" instead an adverb phrase "Of course".