Issue
Issue noun - A condition or occurrence traceable to a cause.
Usage example: one of the issues of the Civil War was a resolution to the question of states' rights
Side effect and issue are semantically related. In some cases you can use "Side effect" instead a noun "Issue".
Side effect
Side effect noun - Any adverse and unwanted secondary effect.
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Synonyms for Side effect
Issue and side effect are semantically related. Sometimes you can use "Issue" instead a noun phrase "Side effect".
Mutual synonyms
Both terms in one sentence
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This has the side effect of preventing other comics in which he appeared from being collected in trades - most notably an issue of Heroes for Hire.
Source: Exiled from Continuity -
It was only at very high doses that the mind was sufficiently enhanced to manifest prescience; and for the addiction and fatal withdrawal symptoms to be an issue (and for the blue-within-blue eyes side effect to show up).
Source: Green Rocks
Cite this Source
Side effect and Issue. (2016). Retrieved 2026, July 21, from https://thesaurus.plus/related/issue/side_effect
Issue & Side effect. N.p., 2016. Web. 21 Jul. 2026. <https://thesaurus.plus/related/issue/side_effect>.
Side effect or Issue. 2016. Accessed July 21, 2026. https://thesaurus.plus/related/issue/side_effect.
Google Ngram Viewer shows how "issue" and "side effect" have occurred on timeline