Know-how and Up on

Know-how noun - Knowledge gained by actually doing or living through something.

Up on and know-how are semantically related In some cases you can use "Up on" instead an adjective phrase "Know-how".

Up on adjective - Being up to particular standard or level especially in being up to date in knowledge.

Know-how and up on are semantically related in knowledgeable topic. Sometimes you can use "Know-how" instead an adjective "Up on".