Lead to
Significant and lead to are semantically related. In some cases you can use "Significant" instead an adjective "Lead to".
Significant
Significant adjective - Clearly conveying a special meaning (as one's mood).
Lead to and significant are semantically related. Sometimes you can use "Lead to" instead an adjective "Significant".
Both terms in one sentence
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Pretty much every character in Fruits Basket has at least one flashback showing a significant moment that lead to them being the way they are.
Source: Origins Episode -
The Doctor tells him in a significant way that trivial things often lead to great discoveries.
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In what would likely be an Amusing Injuries situation in most works, they instead have her suffering multiple broken bones that lead to her being in a magical coma for a significant portion of the book.
Cite this Source
Significant and Lead to. (2016). Retrieved 2026, August 16, from https://thesaurus.plus/related/lead_to/significant
Lead to & Significant. N.p., 2016. Web. 16 Aug. 2026. <https://thesaurus.plus/related/lead_to/significant>.
Significant or Lead to. 2016. Accessed August 16, 2026. https://thesaurus.plus/related/lead_to/significant.
Google Ngram Viewer shows how "lead to" and "significant" have occurred on timeline