Main
Main adjective - Coming before all others in importance.
Usage example: this is the main point of the study—everything else is secondary
Supreme is a synonym for main in principal topic. In some cases you can use "Supreme" instead the word "Main" as an adjective or a noun, when it comes to topics like chief.
Mutual synonyms
Both words in one sentence
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In Star Ocean: The Second Story, while all main characters can become Supreme Chefs thanks to the Skill System, Chisato, Rena, and Yarma are those who canonically apply.
Source: Supreme Chef -
However, the game never reveals who the supreme Blackguard leader is, making Hammerman and his Co-Dragons Dr T and Gearheart than main opponent of the game.
Source: Video Game / Boom Beach - Supreme Commander the Aeon Illuminate who follow a religion called The Way, their main goal is to spread The Way to humanity, but are willing to cleanse all non-believers.
Source: Scary Amoral Religion
Cite this Source
Supreme and Main. (2016). Retrieved 2026, August 16, from https://thesaurus.plus/related/main/supreme
Main & Supreme. N.p., 2016. Web. 16 Aug. 2026. <https://thesaurus.plus/related/main/supreme>.
Supreme or Main. 2016. Accessed August 16, 2026. https://thesaurus.plus/related/main/supreme.
Google Ngram Viewer shows how "main" and "supreme" have occurred on timeline