Misfortune and Meltdown

Misfortune noun - Bad luck or an example of this.

Meltdown and misfortune are semantically related in catastrophe topic. In some cases you can use "Meltdown" instead a noun "Misfortune".

Meltdown noun - Severe overheating of the core of a nuclear reactor resulting in the core melting and radiation escaping.

Misfortune and meltdown are semantically related in calamity topic. Sometimes you can use "Misfortune" instead a noun "Meltdown", if it concerns topics such as catastrophe.