Of course and Without doubt

Of course adverb - As might be expected.

Without doubt and of course are semantically related in exclamation topic. In some cases you can use "Without doubt" instead an adverb phrase "Of course".

Of course and without doubt are semantically related in exclamation topic. You can use "Of course" instead an adverb phrase "Without doubt", if it concerns topics such as certainly, yes, unquestionably, unmistakably.