Operate
Operate verb - To control the mechanical operation of.
Usage example: do not operate heavy machinery, including cars, after taking this medication
Run is a synonym for operate in work topic. In some cases you can use "Run" instead a verb "Operate", when it comes to topics like manage, perform, activity, control. popular alternative
Mutual synonyms
Common collocations
Both words in one sentence
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The Magnificent Seven series: Vin Tanner used to operate as a bounty hunter; dramatic irony kicked in when he was framed for murder and had to go on the run himself.
Source: Bounty Hunter - Rygart from Break Blade is the Trope Namer, having no power over quartz and consequently being unable to operate any complex machinerynote since everything in his world is run by quartz-power, with the exception of an ancient and super-powerful golem that refused to respond to anyone else.
Source: Un-Sorcerer -
Similarly, a large number of structures (and units) either require power to operate at all or have additional features that require power to run.
Source: Video Game / Supreme Commander
Cite this Source
Run and Operate. (2016). Retrieved 2026, July 21, from https://thesaurus.plus/related/operate/run
Operate & Run. N.p., 2016. Web. 21 Jul. 2026. <https://thesaurus.plus/related/operate/run>.
Run or Operate. 2016. Accessed July 21, 2026. https://thesaurus.plus/related/operate/run.
Google Ngram Viewer shows how "operate" and "run" have occurred on timeline