Operose and Uphill

Operose adjective - Characterized by effort to the point of exhaustion; especially physical effort.

Uphill and operose are semantically related In some cases you can use "Uphill" instead an adjective "Operose".

Uphill adjective - Requiring considerable physical or mental effort.

Operose and uphill are semantically related in difficult topic. Sometimes you can use "Operose" instead an adjective "Uphill".