Significant
Significant adjective - Clearly conveying a special meaning (as one's mood).
Vain is an antonym for significant.
Vain
Vain adjective - Having too high an opinion of oneself.
Both words in one sentence
- Even when Hogan himself arrived to the company, he was playing a tired-looking version of his old character, having lost significant muscle mass and trying in vain to exude the charisma he held in his WWF heyday.
Cite this Source
Vain and Significant. (2016). Retrieved 2026, August 13, from https://thesaurus.plus/related/significant/vain
Significant & Vain. N.p., 2016. Web. 13 Aug. 2026. <https://thesaurus.plus/related/significant/vain>.
Vain or Significant. 2016. Accessed August 13, 2026. https://thesaurus.plus/related/significant/vain.
Google Ngram Viewer shows how "significant" and "vain" have occurred on timeline