Despite and Howbeit

Despite noun - Open dislike for someone or something considered unworthy of one's concern or respect.

Howbeit and despite are semantically related In some cases you can use "Howbeit" instead the word "Despite" as an adverb or a conjunction or a preposition.

Howbeit adverb - In spite of that.

Despite and howbeit are semantically related in still topic. Sometimes you can use "Despite" instead the word "Howbeit" as an adverb or a conjunction or a preposition, if it concerns topics such as while, although, in spite of.