Despite and Though

Despite noun - Open dislike for someone or something considered unworthy of one's concern or respect.

Though and despite are semantically related In some cases you can use "Though" instead the word "Despite" as a conjunction or an adverb or a preposition.

Though adverb - In spite of that.

Despite and though are semantically related in while topic. You can use "Despite" instead the word "Though" as a conjunction or an adverb or a preposition.